If you're running a mono board into one amp, you're doing one of two things: everything into the amp's input, or your wet effects (modulation, delay, reverb) routed through the amp's effects loop instead. That second option is four cable method, and it's called that because it takes four instrument leads to wire up.
1. Guitar into your first pedal is cable one.
2. After your last dry effect (overdrive, compression, distortion) into the amp's input is cable two.
3. From the amp's effects send into your first wet pedal is cable three.
4. From your last pedal, usually a reverb, back into the amp's effects return is cable four.
Four leads, four cable method.
Here's what's actually happening inside the amp. Every amp has a preamp section, where you get your tone, your gain, your channel switching (overdrive) if you have it, and a power amp section. The power amp takes that preamp signal and raises volume and power so it can drive your speakers. When everything runs into the front of the amp, all of your effects, dry and wet, are hitting that preamp before the power amp ever sees them. Four cable method just moves the preamp in with your dry effects. Picture it sitting on your board like another overdrive pedal. Your dry effects feed the preamp, the preamp feeds your modulation and wet effects, and then it's on to the power amp and speaker.
Neither wiring is right or wrong. They're just different, and one will probably suit what you're going for better than the other.